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Muscle Building Hormones: The Science of HGH & IGF-1 | Thomas DeLauer

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Muscle Building Hormones: The Science of HGH & IGF-1 | Thomas DeLauer…. I want to talk about some of the hormones that are responsible for tissue growth, responsible for muscle growth, but I also want to address some of the pressure that you might be feeling from the industry and sometimes even from your doctor when it comes down to human growth hormone or IGF. Human growth hormone and IGF are two very, very similar hormones within the body, and what I mean by that is they do very similar things, but, at the same time, they're also very, very different.

What happens is your pituitary gland creates something called human growth hormone. This human growth hormone circulates throughout the course of the body and eventually hits the liver. When it hits the liver, it triggers the release of something known as IGF, insulin-like growth factor-1. The first misnomer that we have to address when we're looking at human growth hormone and we're looking at muscle growth, in general, is that human growth hormone doesn't directly allow muscles to grow. Human growth hormone indirectly activates IGF, which, therefore, allows muscles to grow through a couple of different pathways.

You see, not only do we create insulin-like growth factor in the liver, but we also create it at different localized areas throughout the body, in the skeletal muscle and in the bone. That's exactly why, hormonally, your body starts to build muscle when you train a specific area.

When we look at things like this, it would be easy to assume that if we utilized human growth hormone, we'd be able to produce more muscle, but let's understand how this works a little bit more. You see, human growth hormone is usually secreted through periods of growth, naturally, whenever your body biologically feels that it needs to grow. Adolescence is a perfect example. You're going to be secreting human growth hormone in a pulsatile fashion, and you're usually secreting it throughout the evening time or within the night time when you're asleep, but you're also going to secrete it when you're consuming copious amounts of protein at one sitting, simply because of the amino acid arginine, but you're also going to stimulate it through intense exercise.

First off, we have to understand when the body is producing it, and that helps us understand when you would actually need it. Believe it or not, it's being discovered in a lot of studies, that unless you're deficient in human growth hormone, you're not going to get much benefit out of adding it into your body.

We're going to address the human growth hormone side of things a little bit more when we look at some of the studies later in this video, but, first, let's talk about what IGF is and how this process works. You see, most of the anabolic responses that we're getting from human growth hormone, again, aren't a result of human growth hormone. They're a result of IGF. Let's talk about IGF. You see, IGF stands again for insulin-like growth factor, and what that means is it's very, very structurally similar to insulin.

If you've watched my other videos, you know that insulin is the absorptive hormone. It's the hormone that turns your body into absorptive mode, meaning it's easier to store carbohydrates and it's easier to store fat and, ultimately, even easier to store a little bit of muscle, too.

References:
1) Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models. (n.d.). Retrieved from

2) Claims for the anabolic effects of growth hormone: a case of the Emperor's new clothes? (2003, April 1). Retrieved from

3) Butterfield GE , et al. (n.d.). Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women. - PubMed - NCBI. Retrieved from

4) Growth Hormone Therapy for the Elderly: The Fountain of Youth Proves Toxic. (1993, October 13). Retrieved from

5) Role of microRNAs in skeletal muscle hypertrophy. (n.d.). Retrieved from

6) Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models. (n.d.). Retrieved from

7) Fryburg DA , et al. (n.d.). Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. - PubMed - NCBI. Retrieved from


Muscle Building Hormones: The Science of HGH & IGF-1 | Thomas DeLauer



GenF20™ Look Younger, Feel Younger, Stay Younger With HGH

42 comments:

  1. But Intermittend fasting lowers IGF 1 soooooo?

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  3. Thomas: been following you for years. What are your thoughts on Sermorelin?

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  4. AR receptor???? You can have high levels of growth factors in your blood steam, but a poor level of AR sensitivity. AL-Carnitine improves AR sensitivity, and passes the blood brain barrier.

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  5. when you say exercise hard, does that mean strength training ? lifting heavy ?

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  6. Can someone inform me if serovitale powder breaks a fast?

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  7. Does igf cause eye edema or any retinal inflammation?

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  8. You ramble on at high speed hardly taking a breath... is it to show how much YOU know? or are you just high? Stop trying to squeeze EVERYTHING into one vid... Do less, but help people to learn - not struggle to understand what the heck you're racing through.

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  10. Of course you have to lift to see a muscle increase. Duh! WTF LOL

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  11. I tore my upper left pectoral 11cm and doctor said it can't be surgically reattached because its muscle on muscle tissue tear, my left tit literally hangs lower Slightly, can growth hormones help me heal this injury at all? I cant even perform a simple pull up, in high school 6 years ago I was benching over 400lbs, im so depressed now do I have any hope with growth hormones an opinion would really be helpful

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  12. HGH increases cancerous growth?

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  13. If you use steroids, does it work differently?

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  14. I'm confused! What about the person who was fat and balancing himself with steroids? Go to the library and tell everyone what he read? And what if one day the pharmacy closes? Will he teach us how to be a 50 kg vegan? Or what .... ?

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  15. Thomas, which are you on? HGH or steroids? With your Keto diet

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  16. Thomas why are bodybuilders injection HGH? should i expect to see bodybuilder-like gains through intermittent fasting?thanks

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  17. Thomas please do a video on Thymosin B4 TB500 I have been using it and I am over the moon with the anti-aging and regeneration aspects of it. I think it’s a fantastic subject for a video

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  18. Thomas every time you are so passionate and keen in explaining a topic, I don't quite get it, maybe there're lots of biological or physiological terminology I have not much idea what you're trying to convey to us, plus you're talking so so fast in the way of releasing more information to us audiences yet the promptness really cramped up the most crucial points. For your videos I would recommend for more professional people in nutrition, sports or medical to listen to.

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  19. ▒░░Thomas, most of your videos are great and helpful..Thanks so much
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    ReplyDelete
  20. Omg this guy is talking way too fast! I like that he gives scientific examples and refers to studies, but it’s a lot of information, which I have to stop and google. It’s very hard to listen to and process at this speed. Also it just makes it sound a bit neurotic and makes me kind of gasping for breath.

    I’m totally confused. IGF1 is increased or decreased by fasting???

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  21. Great video, but the cuts to stock video clips are super annoying. If they delivery valuable content, that's great, but otherwise, they make this feel like a generic mass produced video.

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  23. My forearm is short . But strong. Why my forearm is short how this happen... Is this any simple. I very interested to know the truth. Plz help me

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  24. Hi Thomas!! Love your videos and the fact you provide unbiased scientific nutrition and fitness information. I am a CPT w/ specialized certifications in weight loss and nutrition. As a 52 ye old woman, I have used and promote the use of semorelin and ipamorelin for the youthful and muscle building effect ( not mention improved skin, sleep, fat loss). You mentioned that IGF-1 products can trigger tumor and/or unwanted tissue growth. Can you direct me to some more information on this as I would like to be aware of the risks involved for myself and my clients? Thank you!!!

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  26. Fatty liver and IGF1 video please

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  27. How is no one talking about igf-1 levels being what they check for when looking for cancer ... HGH has been known to make everything grow, this means cancer cells and your heart valves 🤷🏼‍♂️

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  28. Moral of the story don't fuck with your hormones for no reason

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  29. You just cant produce enough testosterone naturally compared to foreign agents. Thats why these guy's natural test shuts down. Because the foreign consumption far overpowers natural production that the body tricks itself into thinking it doesnt need to produce any more.

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  30. Awe, so much info in so short time, ok forget i said that.
     
    Please do a video on exogenous L-leucine triggering mtor and how we can use it , or if thats not worth it.

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  31. Wow Thomas! I am 62 years old and this info was so helpful. Love your videos!

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  32. scam artist
    he is on hgh and saying you don't need it, wow what a piece of shit guy

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  33. Superb break down.. In regards to HGH it is secreted during intense periods of weight training, in take of the free form of luicene with our food = proper diet we will see an increase in HGH .. It is the recovery hormone .. Sleep is about 60 percent of our training and growth without it we will be deficient. Key Magnesium and proper diet and knowing ones threshold overtraing without the keys of training and pros we get our info from such as Thomas .. We will age faster get sick etc. Yet the whole point of this channel is to try prevent that along with inspire obviously. Love the channel thanks for being an inspiration.

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  34. Please please please.. Do a vedio on how HGH increase not just muscle but bones,please explain how fasting increase hgh to grow taller. 🙏

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  35. Thank you so much for sharing your knowledge Thomas DeLauer
    .
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    i Just gained no more than 4 inches height with this product without doing any exercise

    ReplyDelete
  36. If HGH help with collagen production help tighten your skin that alone is a great reason to take it. Also you didn't cite enough facts about these proposed case studies to really see the difference in strength game with guys taking HGH versus guys not taking HGH but still working out

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  37. Hey @thomasdelauer. I look like you when you were super “swole” and got married. I know you have leaned out to the max & I would like to know your exact meal/workout plan. Please let me know or sell to me. Thanks bud!!

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  38. this guy is full of shit. he is juiced up. he takes hgh . he is a snake oil seller.

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  39. OK so the 2000 % increase in hgh during IF won't benefit muscle gain much compared to someone else who's not on IF but doing the same amount of weight training?

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